Michelle Skaff shares how one “cellular biohack” pulled her out of chronic pain, and why she believes oxidative stress is the quiet root of aging, inflammation, and so many chronic issues.
We talk antioxidant enzymes in plain English, why most supplements don’t solve oxidative stress at the source, and how community + purpose can be as health-changing as any protocol.
We talk about:
04:40 - What NRF2 is and how it helps reduce oxidative stress at the cellular level
10:10 - Understanding SOD (superoxide dismutase) and why antioxidant enzymes matter for aging
12:35 - Explaining oxidative stress with the “apple browning” analogy
15:35 - Why the same intervention works differently at 20 vs 80
17:40 - Using the “cellular traffic lights” framework (NRF2, mitochondria, NAD)
20:30 - Connecting oxidative stress to inflammation and aging hallmarks
28:30 - Debunking the “it’s just aging” myth behind joint pain
31:35 - Building a simple good/better/best starting stack for inflammation + joints
37:10 - Testing gut health and why Tiny Health stood out
42:35 - Why community and purpose are emerging longevity tools
Questions answered in this episode:
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What does “biohacking” actually mean in a practical, non-bro-science way?
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What is oxidative stress, and why does it accelerate aging?
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What are SOD, catalase, and glutathione, and why do they matter for longevity?
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Why can the same intervention look wildly different in a 20-year-old vs an 80-year-old?
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How can cellular signaling pathways like NRF2 support healthier aging?
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Why do many people take supplements but still feel inflamed, tired, or stuck?
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What’s a realistic starting “stack” for joints, inflammation, and aging?
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Why is collagen about more than beauty and how does it connect to joints and gut lining?
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How does gut health connect to hormones, cravings, and long-term vitality?
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Why do purpose and community matter for health outcomes—especially for women and moms?
Sponsors:
- Join me in Costa Rica for Optimize Her, a 5-night luxury women’s retreat in Costa Rica with yoga, healing rituals, and biohacking workshops—only 12 spots available.
Resources:
- The Only Non-Toxic Baby Registry Guide You’ll Ever Need — and It’s Free
- Explore my luxury retreats and wellness events for women.
- Shop my faves: Check out my Amazon storefront for wellness essentials.
- Michelle Skaff’s Instagram
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