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Inflammation, Hormones, and the Truth About NAD: Longevity That Feels Steady, Not Extreme with Dr. Nichola Conlon

Inflammation, Hormones, and the Truth About NAD: Longevity That Feels Steady, Not Extreme with Dr. Nichola Conlon

Dr. Nichola Conlon, molecular biologist, NAD⁺ researcher, and CEO of Nuchido (code: BIOHACKINGBRITTANY), unpacks inflammation, mitochondrial energy, and biological age through a clear, female-first lens. 

She discusses how NAD⁺ decline intersects with hormones and stress, why over-fasting and all-out training can backfire, and when to prioritize nervous-system safety in seasons like postpartum and perimenopause. 

Expect practical ways to test what matters, calm hidden inflammation, and switch on your cells’ own NAD⁺ production—so longevity feels steady, not extreme.

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We talk about: 

05:40 - The shift from lifespan to healthspan and why women lose two decades to chronic disease

08:20 - Healthspan defined: Living longer healthier, not just longer

11:45 - Why aging is reversible at the cellular level

13:25 - Biological vs. chronological age and why the gap matters

16:35 - Why inflammation-based metrics can be more actionable

20:15 - How pregnancy, stress, and perimenopause affect inflammation

23:20 - NAD⁺ 101: Energy, repair, and resilience for women’s bodies

25:45 - The NAD decline curve (and how lifestyle accelerates or slows it)

33:05 - Inside Nuchido’s approach: Switch on your own NAD production

38:20 - What’s next for NAD research and everyday habits that help

43:15 - Nature + botanicals: Honoring biology in a modern world

Questions answered in this episode: 

  • What changed in longevity science—and why “healthspan” comes first now?

  • How do you know if you’ve moved out of your healthspan?

  • Biological vs. chronological age: what’s the difference and why it counts?

  • Which age tests are most useful for real decisions at home?

  • Why do inflammation-driven measures often reflect your true “age”?

  • How pregnancy, postpartum, and perimenopause shift inflammatory load

  • What is NAD⁺ and how does it impact energy, repair, and resilience?

  • At what age does NAD⁺ meaningfully decline and how fast?

  • Can over-fasting and over-training raise your biological age (especially for women)?

  • Why “turning on” your own NAD production may beat dumping in precursors

  • What does good human clinical evidence for an NAD product look like?

  • Daily habits that naturally support NAD⁺ without stressing your system?

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