How Histamine Intolerance Could Be Sabotaging Your Gut, Hormones, and – Biohacking Brittany

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May 23, 2025

How Histamine Intolerance Could Be Sabotaging Your Gut, Hormones, and Mood—And How to Fix It with a Functional Medicine Approach

After tons of messages, I’m breaking down our detox journey—why we’re doing it, what we tested, and the shocking histamine link we discovered.

This goes beyond gut health—it's about how your genes, hormones, and mood are all connected. I break down histamine intolerance, key symptoms, and how you might be unknowingly sabotaging your health.

I talk about:

06:40 – The functional medicine testing we did (Tiny Health code: BIOHACKINGBRITTANY, DUTCH Test, The DNA Company)

10:00 – Symptoms of gut issues and the genetic links to high histamine, estrogen dominance, and chronic symptoms

20:55 – Histamine-producing gut bacteria and symptoms of histamine intolerance

27:20 – Biomarkers to look for in your blood test (Siphox code: BIOHACKINGBRITTANY)

34:00 – What a low-histamine diet looks like (and what foods to avoid)

36:00 – The exact 6-week protocol we're using

38:00 - Phase 1: Pathogen Elimination (Designs for Health G.I. Microb-X, Progressive Labs GastroPro)

40:50 – Phase 2: Detox Support (GI Detox+, SH Stress Nutrients + SH Riboflavin, Xymogen OptiMag Neuro, BiOptimizers Magnesium Breakthrough code: BIOHACKINGBRITTANY, WeNatal code: BIOHACKINGBRITTANY)

43:08 – Phase 3: Microbiome Rebuilding (Designs for Health Floromyces, Seed Probiotic, BiOptimizers Probiotic code: BIOHACKINGBRITTANY)

44:30 – Phase 4: Hormone & Nutrient Optimization (BiOptimizers MassZymes code: BIOHACKINGBRITTANY, WeNatal & Men’s Multi code: BIOHACKINGBRITTANY, Baja Gold Salt code: BIOHACKINGBRITTANY)

49:40 – What happens after the protocol ends and how to reintroduce foods

Questions answered in this episode:

What is histamine intolerance, and what are the symptoms?
How do gut health and hormone imbalances relate?
Which bacteria produce histamine and how do you test for them?
What do MTHFR, DAO, and COMT genes mean for detox?
What does a low histamine diet include?
What is the best testing protocol for gut and gene health?
How do you reintroduce foods and track results after a gut reset?

Sponsors:

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Resources:

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Dr. John Thomas, Functional Medicine Specialist