GLP-1s are peptides. The P literally stands for peptide. Your body makes its own GLP-1 after every single meal, and it's gone within a couple of minutes by design. The drugs are that same signal, engineered so it never goes away, and that one difference explains both how well they work and almost everything women struggle with on them.
In this episode I break it all down. What a peptide actually is, how peptide drugs are built, and what your own GLP-1 does in your body. Then how to raise your own GLP-1 with protein, soluble fiber, healthy fats, fermented foods, meal order and how fast you eat, with real meal ideas (and why fasting doesn't raise it the way people think).
Then I go drug by drug: semaglutide (Ozempic, Wegovy, Rybelsus), tirzepatide (Mounjaro, Zepbound), retatrutide, the new oral GLP-1 pill, and generic semaglutide here in Canada. We talk half-life and steady state, what the labels actually say about dosing, what microdosing really means, what's different for women (bone, muscle, fertility and hair loss), and what happens when you come off.
I start with a personal story too: I sliced my finger open this week, and how my meditation practice let me regulate my nervous system in the ER.
This is for education, not medical advice. If you want to do this work with me, work with me one on one. I see women every week for peptides, nervous system, nutrition and longevity, and you can book a free 15 minute call with me here.
Join The LongHer Life Online Community for women-specific guidance on peptides, hormones, longevity and soul.
Timestamps
- 00:00 - Slicing my finger, the ER, and regulating my nervous system in an emergency
- 08:50 - Why my peptide content is moving off Instagram, and what's in this episode
- 10:10 - What a peptide is, and how peptide drugs are built to last
- 17:34 - Your own GLP-1: what it does, why it's gone in minutes, and food noise
- 26:30 - Raising your own GLP-1: protein, fiber, fats, meal order, CGMs and meal ideas
- 44:54 - Fasting and GLP-1
- 46:35 - Half-life, steady state, and what happens when you stop
- 53:30 - Semaglutide, tirzepatide, retatrutide, the new GLP-1 pill and generics in Canada
- 1:04:06 - Dosing and microdosing
- 1:10:15 - What's different for women: bone, muscle, fertility and hair
- 1:18:12 - Coming off, side effects, and questions to ask yourself
- 1:22:09 - Peptides in food, rhythm vs signal, and the close
Resources
- Work with me one on one.
- Book a free 15 minute call with me.
- My free GLP-1 boosting recipe booklet for women is coming soon. Follow me on Instagram or Substack to hear when it drops.
- Join The LongHer Life Online Community.
- Read my peptide content on Substack at The LongHer Life.
Products mentioned
- FreeStyle Libre 3 continuous glucose monitor (Canada)
- Signos continuous glucose monitor program (US)
- A DEXA scan for bone density and lean mass
Let's connect
- Instagram @biohackingbrittany
- Shop everything I use at biohackingbrittany.com
- Listen on Spotify, Apple Podcasts, and YouTube Music
This is for educational purposes only. This is not medical advice. Some links are affiliate links.