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Women’s Health After 40: Hormones, Bone Loss, and Longevity with Dr. Mani Kukreja

Women’s Health After 40: Hormones, Bone Loss, and Longevity with Dr. Mani Kukreja

Dr. Mani Kukreja, physician and integrative wellness expert, breaks down the misunderstood reality of women’s health after 40—from stress and hormonal decline to bone loss and accelerated aging.

We unpack why women’s fatigue, belly weight, and brain fog are often dismissed—and how stress and estrogen decline drive it. Dr. Mani shares strategies from Age Stronger, Live Longer on movement, protein, sleep, and testing as true foundations for longevity.

Listen to learn the “gym bro” secrets women over 40 actually need—impact training, weightlifting, and protein cycling—to stay strong, protect bones, and cut disease risk.

We talk about: 

10:00 – Why women’s health declines faster after 40

15:30 – The overlooked foundations for longevity

18:00 – Movement as medicine and the biology of bone health

23:20 – Why women need impact training and weightlifting

37:40 – Why most women are hesitant to strength train

40:20 – Sleep, stem cells, and Alzheimer’s risk

43:10 – The blood tests that you need to take

51:45 – Cholesterol, inflammation, and genetic predisposition

55:30 – Why pregnancy is an inflammatory condition

Questions answered in this episode: 

  • Why do women experience faster health decline after 40?

  • How does stress and estrogen loss accelerate aging?

  • What are the foundational practices for longevity every woman should start today?

  • Why is movement—especially impact and resistance training—critical for bone health?

  • How much protein do women really need daily, and why is timing important?

  • What blood tests reveal the truth about metabolic and hormonal health?

  • How does chronic inflammation drive aging and disease risk?

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